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. 2020 Nov 20;22(1):77–91. doi: 10.1007/s10561-020-09867-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — hADSCs-Exos enhanced the proliferation and migration of hADSCs. A CCK-8 analysis of hADSCs after treatment with exosomes (10, 15 and 20 μg/mL) from hADSCs after 14 days of osteogenic differentiation (Exo^1−14d) for 24, 48, and 72 h. B, C Migration of hADSCs co-cultured with different concentration of Exo^1−14d (10, 15 and 20 μg/mL) assessed by wound healing assay in 0 h, 12 h and 24 h. Scale bar = 200 μm. The quantitative results of wound healing assay.PM: proliferation medium; **p < 0.01 compared with PM group, ^###p < 0.001 compared with 15 μg/mL Exo^1−14d group