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Basal and induced NR4A1 in blood-derived tumors-low expression of NR4A is observed in most blood-derived tumors due to promoter paused RNA Pol II and DHE induces NR4A tumor-expression through recruitment of the super elongation complex (49). There is also evidence for cytoplasmic NR4A in some lymphomas (42) and the retinoid Fenretinimide also induced nuclear export of NR4A1 which formed a complex with bcl-2 (51).
