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. 2021 Feb 5;4:165. doi: 10.1038/s42003-021-01696-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic explanation of the experiment. Behavior of orexin neuron-ablated male mouse was video observed with regular chow, chocolate, or female for 12 h. b The number of cataplexy-like bouts during the dark period (ZT12–ZT24) in three treatment groups. Two-way ANOVA (treatment: regular chow, chocolate, female × period: bin length of 2 h) revealed that there was a significant difference in the number of cataplexy-like bouts during the dark period among treatments (F_2,15 = 4.094, P = 0.0381) and between time points (F_5,75 = 5.723, P = 0.0002). The interaction was not significant (F_10,75 = 1.148, P = 0.3395). c The number of cataplexy-like bouts during the light period (ZT0–ZT12) in three treatment groups. There was a significant difference among treatments (F_2,15 = 20.85, P < 0.0001) and between time points (F_5,75 = 6.639, P < 0.0001). The interaction was also significant (F_10,75 = 5.368, P < 0.0001). d Summary for light/dark period over 12 h. Overall, the number of cataplexy-like bouts was higher during the dark period than during the light period (F_1,15 = 99.19, P < 0.0001). Note that both chocolate and female encounter increased the number of cataplexy-like bouts during the dark period compared to regular chow. Only female encounter increased the number of cataplexy-like bouts during the light period. The effect of the female encounter on number of cataplexy-like bouts was short-lived and gradually decreased toward regular chow level over 6 h. Data are expressed as mean ± SEM. n = 6 for each group. *P < 0.05 as compared to regular chow.