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. 2021 Feb 5;4:163. doi: 10.1038/s42003-021-01686-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Traffic analysis of triglyceride variables; b, routing diagram of the switch analysis of triglyceride (measured in positive ionisation mode) and phosphatidylcholine (measured in negative ionisation mode) variables in F1 neonatal mice re-routed from the serum-heart in the control group to the serum-brain in the experimental group. TG and PC variables on the serum-heart axis in the control (NP-NC, blue) group of F1Ns that are found on the serum-brain axis of the experimental (LP-HC, orange) group of F1Ns but not their serum-heart axis. The pie charts in the insert show the number of ubiquitous lipid variables for that network, for each phenotype. Larger pie charts represent lipids found in two adjacent compartments (B-type lipids). Smaller pie charts represent lipids found in isolated in compartments (U-type lipids). J represents the Jaccard-Tanimoto coefficient for the comparison, with accompanying p value, as a measure of the similarity between the variables identified in the two phenotypes for each comparison. The p value shown represents the probability that the difference between the lists of variables for the two phenotypes occurred by random chance. Orange is used for the LP-HC group, whereas blue is used for the NP-NC group. Cer, ceramide; Chol, cholesterol; DG, diglyceride (water-loss product from fragmentation in source); LPC, lyso-phosphatidylcholine; LPE, lyso-phosphatidylethanolamine; LPG lyso-phosphatidylglycerol; PA, phosphatidic acid; PC, phosphatidylcholine; PC-O, phosphatidylcholine plasmalogen; PE, phosphatidylethanolamine; PE-O, phosphatidylethanolamine plasmalogen; PG, phosphatidylglycerol; PI, phosphatidylinositol; PS, phosphatidylserine; SM, sphingomyelin; TG, triglyceride.