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. 2021 Feb 5;11:3263. doi: 10.1038/s41598-021-82944-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Specific dome knockdown in fat body cells reverses the effects of a high-sugar diet. Canton-S, control (mCD8-GFP), and Dome knockdown (Dome-IR) larvae were reared on ND for 72 h and HSD for 120 h. (A) Bodyweight (n ≥ 30 animals at least 4 independent experiments), (B) Hemolymph glycemia (n = 70 larvae per pool, N ≥ 3 independent experiments) and (C) Hemolymph TAG levels (n = 70 larvae per pool, N ≥ 3 independent experiments) of larvae fed with ND or HSD. (D) Lifespan curve of Dome-IR and mCD8-GFP adult male flies fed a ND or HSD (n = 300 animals per conditions). Relative expression by qPCR to dilp2 in brain cells (E), dilp6 (F), and dilp2 (G) in fat body cells of Dome-IR and mCD8-GFP larvae in HSD (n = 25 per group, N = 3 independent experiments). The dotted line (black) represents the relative expression by qPCR of mCD8-GFP and Dome-IR larvae fed with ND. Bars represent mean ± SD. 2-way ANOVA followed by Bonferroni's multiple comparisons test was used to derive all p values. ***p < 0.001, **p < 0.01, *p < 0.05. ^###p < 0.001, ^##p < 0.01, ^#p < 0.05 respect to ND control.