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. 2021 Feb 5;12:802. doi: 10.1038/s41467-021-21121-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a SEM image with 1 µm scale bar of silica core, b silica-methylene blue (SiMB), and c silica-acridine orange (SiAO) composite particles with diameter sizes (ϕ) which are presented as mean values ± standard deviation (SD), n = 10. d Target gene, universal capture probe, and gene-specific reporter probe binding regions on the circular DNA template. e Gel representation of RCA amplicons visualized on 0.8% agarose gel electrophoresis (n = 3). Lane M indicates the 1 kb DNA ladder, while lanes 1, 2, and 3 indicate the RCA amplicons of both N and S genes, N gene only, and S gene only, respectively. Source data are provided as a Source Data file.