Table 1.

Binding of Pangolin-CoV and SARS-CoV-2 S to ACE2s from different species.

Spike	ACE2	Kd amplitude (nM)	Kd kinetics (nM)
SARS-CoV-2	Human	110 ± 14.7	75.5 ± 12.9
	Pangolin	987 ± 112	896 ± 225
Pangolin-CoV	Human	74.0 ± 13.0	42.1 ± 10.0
	Pangolin	850 ± 169	663 ± 139

Equilibrium dissociation constants determined from the analysis of the data in Fig. 1 (K_d Amplitude) compared with values determined from analysis of the corresponding kinetic data (K_d Kinetics) (see Fig. S1).