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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Prog Retin Eye Res. 2020 Aug 6;81:100886. doi: 10.1016/j.preteyeres.2020.100886

Figure 6: Microglia activation during disease progression.

Figure 6:

Naïve microglia undergo inflammatory transition to an activated state (releasing inflammatory cytokines, chemokines) to confer protection during acute infection or tissue injury in the CNS. However, persistent activation of microglia upon stress stimuli rendered by genetic predisposition or environmental factors, leads to a state of hyper activation associated with an uncontrolled release of pro-inflammatory mediators (chronic inflammation), which in turn causes neuronal damage in the CNS.