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. 2021 Feb 5;8:48. doi: 10.1038/s41597-021-00830-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Illustration of subject onboarding. Note that 48 screened subjects did not meet the study inclusion criteria, 10 subjects who met the study inclusion criteria did not consent due to time commitment or having to come to the laboratory in a practically-defined off state, and all subjects that provided consent completed the protocol. However, data from 3 subjects were excluded from the dataset because of protocol change (n = 2) and a considerable amount of missing data (n = 1).