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. 2021 Feb 5;11:25. doi: 10.1186/s13613-021-00814-8

Table 4.

Hazard ratios for multivariable models of 90-day mortality for P-PENK24h > 105.7 pmol/mL and P-NGAL24h > 151 ng/mL

Hazard ratio 95% CI p value* c-statistic c-statistic without PENK/NGAL
P-PENK24h > 105.7 pmol/mL at 24 h
Univariable 5.8 3.1–10.7 < 0.001 0.705
Adjusted model 1 (CardShock risk score) 4.5 2.3–8.7 < 0.001 0.778 0.726
Adjusted model 2 (IABP II SHOCK score) 4.2 2.0–9.0 < 0.001 0.750 0.702
Adjusted model 3 (AKIcrea48h) 3.5 1.7–6.9 < 0.001 0.750 0.671
Adjusted model 4 (CardShock risk score + AKIcrea48h) 2.7 1.3–5.6 0.01 0.800 0.781
Adjusted model 5 (IABP II SHOCK score + AKIcrea48h) 2.7 1.2–5.9 0.01 0.773 0.749
P-NGAL24h > 151 ng/mL at 24 h
Univariable 5.2 2.8–9.8 < 0.001 0.632
Adjusted model 1 (CardShock risk score) 3.4 1.7–6.8 0.001 0.733 0.726
Adjusted model 2 (IABP II SHOCK score) 4.2 2.0–8.9 < 0.001 0.724 0.702
Adjusted model 3 (AKIcrea48h) 3.2 1.6–6.5 0.001 0.716 0.671
Adjusted model 4 (CardShock risk score + AKIcrea48h) 2.0 0.9–4.2 0.07 0.781 0.781
Adjusted model 5 (IABP II SHOCK score + AKIcrea48h) 2.5 1.1–5.9 0.03 0.755 0.749

AKIcrea48h acute kidney injury by creatine increase within 48 h, CI confidence interval, NGAL neutrophil gelatinase-associated lipocalin, PENK proenkephalin

*2 log-likelihood test for additive value of P-PENK/P-NGAL in the model