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. 2021 Feb 5;11:3222. doi: 10.1038/s41598-021-82930-w

Figure 1.

Figure 1

Vaccine-linked chemotherapy efficacy by reducing parasitemia, cardiac parasite burden, inflammatory infiltrate and fibrosis. (A) The parasitemia represented as Area Under Curve (AUC) determined along 53 days post-infection by qPCR. (B) Adjusted scale of AUC showing differences between treatment groups. (C) Cardiac parasite burden was determined by qPCR at 53 dpi. (D) Inflammatory infiltrate cells were determined by 5 representative images from each mouse analyzed by FIJI software from cardiac tissue slides using hematoxylin/eosin staining. (E) Fibrosis percentage was determined by 5 representative images from each mouse analyzed by FIJI software from cardiac tissue slides using trichrome staining. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001 indicate difference when comparing groups to the infected untreated control. $, P ≤ 0.05; $$, P ≤ 0.01; $$$, P ≤ 0.001; $$$$, P ≤ 0.0001 indicate when comparing groups to the low-dose BZN. &, P ≤ 0.05; &&, P ≤ 0.01 when comparing groups to the low-dose E6020.