Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 5;11:3222. doi: 10.1038/s41598-021-82930-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Correlation analyses of cytokines and parasite burdens. Mice were treated either concurrently with high dose vaccine + BZN (100 μg Tc24-C4/25 μg E6020-SE + 25 mg/Kg BZN), or a high dose of BZN (100 mg/kg BZN) starting 7 days post-infection as described. Cardiac parasite burdens were determined by qPCR at 53 days of infection, and parasitemia was measured twice weekly until 53 days of infection by qPCR as described. Cytokine levels were measured from the supernatant of splenocytes restimulated with T. cruzi lysate by Luminex assay as described. Levels of IL-22 were significantly negatively correlated with cardiac parasite burdens in mice treated with high dose vaccine + BZN (A); Levels of IL-17 were significantly negatively correlated with parasitemia (B) and cardiac parasite burdens (C) in mice treated with high dose BZN. Similarly, levels of IL-22 were significantly negatively correlated with parasitemia (D) and cardiac parasite burdens (E) in mice treated with high dose BZN. P ≤ 0.05 were considered statistically significant.