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. 2021 Feb 5;11:3222. doi: 10.1038/s41598-021-82930-w

Table 1.

Survival to T. cruzi acute infection.

Group Percent Survival (%) P value
Infected Untreated 40 N/A
Low dose E6020 90 0.0203*
High dose E6020 90 0.0234*
Low dose BZN 100 0.0039**
High dose BZN (curative) 100 0.0039**
Low dose vaccine 80 0.0598
High dose vaccine 100 0.0039**
Low dose vaccine + BZN 100 0.0039**
High dose vaccine + BZN 100 0.0039**

Mice were infected with 500 trypomastigotes of T. cruzi and followed up daily for up to 53 days post-infection. Percentages of survival were analyzed using Log-rank (Mantel-Cox) test comparing treated groups vs infected untreated group and statistical differences were considered when P values * P ≤ 0.05, ** P ≤ 0.005.