Table 1.
Group | Percent Survival (%) | P value |
---|---|---|
Infected Untreated | 40 | N/A |
Low dose E6020 | 90 | 0.0203* |
High dose E6020 | 90 | 0.0234* |
Low dose BZN | 100 | 0.0039** |
High dose BZN (curative) | 100 | 0.0039** |
Low dose vaccine | 80 | 0.0598 |
High dose vaccine | 100 | 0.0039** |
Low dose vaccine + BZN | 100 | 0.0039** |
High dose vaccine + BZN | 100 | 0.0039** |
Mice were infected with 500 trypomastigotes of T. cruzi and followed up daily for up to 53 days post-infection. Percentages of survival were analyzed using Log-rank (Mantel-Cox) test comparing treated groups vs infected untreated group and statistical differences were considered when P values * P ≤ 0.05, ** P ≤ 0.005.