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. 2021 Feb 6;25:50. doi: 10.1186/s13054-021-03481-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — scRNA-seq uncovers neutrophil transcriptional heterogeneity after LPS stimulation. a UMAP representation of gene expression data in 9421 neutrophils, including the control and LPS-stimulated cells. b Seurat cluster assignment projected onto the UMAP plot. c The proportion of each subset of cells in the control group and the LPS stimulation group. d PD-L1 and MHC-II components (H2-Ob, H2-Eb, H2-Ab1, H2-Aa) expression in different clusters. e Bar plot showing the changes in the proportions of neutrophils expressing PD-L1 or MHC-II components (H2-Ab1) in each cluster. f Heat map of significant differential gene in each cluster. g Pseudotime map showed changes in neutrophil differentiation after LPS stimulation