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. 2021 Jan 26;118(5):e2009156118. doi: 10.1073/pnas.2009156118

Fig. 3.

Fig. 3.

Recovery of follicular development and ovarian Cyp19a1 and Lhcgr mRNA expression in the KNDy neuron-rescued female rats. (A) Ovarian weight of the few, moderately, and highly KNDy-rescued global Kiss1 KO rats and AAV-EGFP–treated global Kiss1 KO control rats (Cont). (B) A Graafian follicle (solid arrowhead) in the ovary of a representative highly KNDy-rescued rat and a non-Graafian tertiary follicle (open arrowhead) in the ovary of a representative control rat. (Scale bars, 200 μm.) (C) The diameter in each Graafian and non-Graafian tertiary follicle in the few, moderately, and highly KNDy-rescued rats and control rats. The tertiary follicle with a diameter greater than 390 µm (horizontal dashed line) was termed as Graafian. (D) The mean numbers of Graafian and non-Graafian tertiary follicles and follicular cysts in each group. (E) The ovarian Cyp19a1, Cyp17a1, Lhcgr, and Fshr gene expression in each group. Values expressed in the bar graphs are mean ± SEM. Numbers in (or on) each column indicate the number of animals used. The values with different letters were significantly different from each other (P < 0.05) based on one-way ANOVA followed by Tukey’s HSD test.