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A positive feedback level of E2-induced surge-like increase in plasma LH levels in the conditional ARC Kiss1 KO female rats. (A) Mean plasma LH profiles in the moderately and highly ARC Kiss1 KO rats and AAV-EGFP–treated Kiss1-floxed control rats (Cont). (B) The ratios of peak to baseline of plasma LH levels. Values expressed are mean ± SEM. Numbers in each column indicate the number of animals used. No significant differences were detected in the ratio by one-way ANOVA.
