Fig. 6.
Wireless measurements of skin hydration on human subjects with atopic dermatitis. (A and B) Mounting positions on the back of the hand (atopic eczema) and the forearm (control) of a young adult patient with severe AD (subject 1; A) and on the chest (inflamed, perilesional, and clinically unaffected skin from Left to Right) of an elderly patient with inflammatory AD (subject 2; B). The studies involve three repeated measurements at each location using wireless and commercial devices before and 15 min after application of moisturizer. The Inset shows optical images of the back of the hand, and forearm immediately after application of moisturizer (A) and of devices on the inflamed (Left; B) and perilesional (Right; B) skin. (C and D) Wireless measurements of ∆T12 before and after (B&A) application of moisturizer from subjects 1 (C) and 2 (D). (E and F) Skin hydration level (Φ) measured using commercial devices for measuring tissue water content (ΦCML,1) and skin surface (ΦCML,2) hydration, and from the values of ∆T12 (ΦBLE) from subjects 1 (E) and 2 (F). The results of ΦCML,1 exhibit strong correlations with ΦBLE after calibration (ΦBLE,Cal = ΦBLE × 0.78–0.08). (G and H) Pictures of the device mounted on the forehead (G) and leg (H; visibly dry skin) of a toddler. (I) Measurements of ΦBLE (blue), ΦCML,1 (black), TEWL (red), and SCH (green) on the left leg (LL), right leg (RL), and forehead (FH). The vertical lines denote the error bars.