Table 7.
Assessment of cytotoxicity of the examined Pulmonaria phenolic-rich fractions towards peripheral blood mononuclear cells and blood platelets in vitro. Viability of control (untreated) PBMCs and LDH leakage in control blood platelets were assumed as 100%; (n = 7–13; p > 0.05).
| Pulmonaria Phenolic-Rich Fraction Concentration [µg/mL] | % Viability of PBMCs Based on Propidium Iodide Assay | % Viability of PBMCs Based on Resazurin Reduction Assay | % of LDH Leakage from Blood Platelets | |
|---|---|---|---|---|
| P. obscura | 1 | 102.15 ± 13.12 | 96.84 ± 8.70 | 100.55 ± 9.04 |
| 5 | 106.80 ± 6.21 | 94.59 ± 8.14 | 99.67 ± 12.50 | |
| 25 | 100.11 ± 9.78 | 95.25 ± 8.68 | 101.16 ± 11.22 | |
| 50 | 105.45 ± 6.52 | 98.53 ± 11.10 | 97.86 ± 6.98 | |
| 100 | 100.21 ± 12.08 | 93.75 ± 8.69 | 94.92 ± 6.84 | |
| P. officinalis | 1 | 102.97 ± 9.32 | 93.71 ± 8.10 | 103.30 ± 13.33 |
| 5 | 106.66 ± 7.05 | 93.76 ± 10.54 | 105.59 ± 15.16 | |
| 25 | 104.18 ± 10.77 | 93.59 ± 9.32 | 102.32 ± 7.57 | |
| 50 | 104.67 ± 9.15 | 96.70 ± 7.51 | 98.68 ± 13.30 | |
| 100 | 107.05 ± 5.53 | 97.33 ± 9.43 | 99.65 ± 7.67 |