Figure 7.

Mechanistic scheme summarizing the anti-inflammatory effect of KMU-1170. LPS, lipopolysaccharide; TLR4, toll-like receptor 4; MyD88, myeloid differentiation factor 88; TAK1, transforming growth factor-β-activated kinase 1; IKK, inhibitor NF-κB kinase; MAPKs, mitogen-activated protein kinases; NF-κB, nuclear factor-κB; iNOS, inducible nitric oxide synthase; COX-2, cyclooxygenase-2; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β; NLRP3, NOD-like receptor family, pyrin domain containing 3; ASC, apoptosis-associated speck-like protein containing a CARD.