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DSB-free insertion of genomic edits using PNAs. Lipid nanoparticle have been used to deliver PNA and single strand DNA (ssDNA) donor templates. After strand invasion by the PNA, the p-loop is recognized by the endogenous DNA repair machinery, which induce the introduction of the desired edits carried by the ssDNA. DSB: double strand break; PNA: peptide nucleic acid; ssDNA: single-stranded DNA.
