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. 2021 Jan 28;13(3):503. doi: 10.3390/cancers13030503

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Simultaneous encapsulation of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and ATTO in cHANPs and ANG-cHANPs. (a) Confocal microscopy images of cHANPs; (b) Fluorescent microscopy images of ANG-cHANPs; (c) Longitudinal relaxation rate (1/T1) in s⁻¹ of free Gd-DTPA in water (grey line), cHANPs (blue line), and ANG-cHANPs (red line), Thera-cHANPs (cyan line); Thera-ANG-cHANPs (violet line) showing a relaxivity r1 of 3.58, 20.32, 12.08, 9.09 and 8.86 mM⁻¹s⁻¹ respectively.