Table 8.
Differentially expressed genes enriched in GO terms in stress-exposed rats responding to chronic lithium treatment in comparison to rats before lithium.
| Go Accession | GO Term | Corr p | No. Genes |
|---|---|---|---|
| downregulated in the amygdala | |||
| GO:0044425 | membrane part | 0.000 | 1150 |
| GO:0032501| | multicellular organismal process | 0.000 | 1107 |
| GO:0031224 | intrinsic component of membrane | 0.000 | 1098 |
| GO:0016021 | integral component of membrane | 0.000 | 1090 |
| GO:0007154 | cell communication | 0.000 | 941 |
| GO:0023052 | signaling | 0.000 | 930 |
| GO:0007165 | signal transduction | 0.000 | 909 |
| GO:0042221 | response to chemical | 0.000 | 895 |
| GO:0071944 | cell periphery | 0.000 | 881 |
| GO:0005886 | plasma membrane | 0.000 | 874 |
| GO:0004871 | signal transducer activity | 0.000 | 773 |
| GO:0038023 | signaling receptor activity | 0.000 | 762 |
| GO:0060089 | molecular transducer activity | 0.000 | 762 |
| GO:0004888 | transmembrane signaling receptor activity | 0.000 | 749 |
| GO:0007186 | G-protein coupled receptor signaling pathway | 0.000 | 736 |
| GO:0003008 | system process | 0.000 | 720 |
| GO:0050877 | nervous system process | 0.000 | 683 |
| GO:0007600 | sensory perception | 0.000 | 667 |
| GO:0004930 | G-protein coupled receptor activity | 0.000 | 652 |
| GO:0007606 | sensory perception of chemical stimulus | 0.000 | 632 |
| GO:0051606 | detection of stimulus | 0.000 | 593 |
| GO:0050906 | detection of stimulus involved in sensory perception | 0.000 | 586 |
| GO:0009593 | detection of chemical stimulus | 0.000 | 578 |
| GO:0050907 | detection of chemical stimulus involved in sensory perception | 0.000 | 578 |
| GO:0007608 | sensory perception of smell | 0.000 | 565 |
| GO:0004984 | olfactory receptor activity | 0.000 | 556 |
| GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | 0.000 | 556 |
| GO:0005549 | odorant binding | 0.000 | 164 |
| GO:0051716 | cellular response to stimulus | 0.000 | 1009 |
| GO:0050896 | response to stimulus | 0.000 | 1174 |
| GO:0016503 | pheromone receptor activity | 0.000 | 48 |
| GO:0019236 | response to pheromone | 0.000 | 47 |
| GO:0016020 | membrane | 0.000 | 1232 |
| GO:0050789 | regulation of biological process | 0.000 | 1346 |
| GO:0065007 | biological regulation | 0.000 | 1417 |
| GO:0050794 | regulation of cellular process | 0.000 | 1286 |
| GO:0033038 | bitter taste receptor activity | 0.000 | 19 |
| GO:0008527 | taste receptor activity | 0.000 | 20 |
| GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | 0.000 | 21 |
| GO:0050909 | sensory perception of taste | 0.000 | 27 |
| GO:0050912 | detection of chemical stimulus involved in sensory perception of taste | 0.000 | 22 |
| GO:0050913 | sensory perception of bitter taste | 0.000 | 21 |
| GO:0030414 | peptidase inhibitor activity | 0.000 | 47 |
| GO:0004866 | endopeptidase inhibitor activity | 0.000 | 44 |
| GO:0061135 | endopeptidase regulator activity | 0.001 | 44 |
| GO:0004252 | serine-type endopeptidase activity | 0.001 | 45 |
| GO:0008227 | G-protein coupled amine receptor activity | 0.003 | 22 |
| GO:0017171 | serine hydrolase activity | 0.003 | 49 |
| GO:0008236 | serine-type peptidase activity | 0.004 | 48 |
| GO:0061134 | peptidase regulator activity | 0.006 | 47 |
| GO:0004867 | serine-type endopeptidase inhibitor activity | 0.016 | 25 |
| GO:0019373 | epoxygenase P450 pathway | 0.030 | 10 |
| GO:0010466 | negative regulation of peptidase activity | 0.037 | 50 |
| downregulated in the frontal cortex | |||
| GO:0004930 | G-protein coupled receptor activity | 0.000 | 50 |
| GO:0007606 | sensory perception of chemical stimulus | 0.000 | 45 |
| GO:0009593 | detection of chemical stimulus | 0.000 | 43 |
| GO:0038023 | signaling receptor activity | 0.000 | 61 |
| GO:0060089 | molecular transducer activity | 0.000 | 61 |
| GO:0007600 | sensory perception | 0.000 | 51 |
| GO:0050907 | detection of chemical stimulus involved in sensory perception | 0.000 | 42 |
| GO:0007608 | sensory perception of smell | 0.000 | 41 |
| GO:0004984 | olfactory receptor activity | 0.000 | 40 |
| GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | 0.000 | 40 |
| GO:0051606 | detection of stimulus | 0.000 | 44 |
| GO:0050906 | detection of stimulus involved in sensory perception | 0.000 | 42 |
| GO:0004888 | transmembrane signaling receptor activity | 0.000 | 56 |
| GO:0007186 | G-protein coupled receptor signaling pathway | 0.001 | 54 |
| GO:0003008 | system process | 0.001 | 63 |
| GO:0004871 | signal transducer activity | 0.002 | 62 |
| GO:0050877 | nervous system process | 0.002 | 54 |
| GO:0016021 | integral component of membrane | 0.006 | 112 |
| GO:0031224 | intrinsic component of membrane | 0.007 | 113 |
| upregulated in the hippocampus | |||
| GO:0004930 | G-protein coupled receptor activity | 0.000 | 118 |
| GO:0007606 | sensory perception of chemical stimulus | 0.000 | 108 |
| GO:0050907 | detection of chemical stimulus involved in sensory perception | 0.000 | 102 |
| GO:0009593 | detection of chemical stimulus | 0.000 | 103 |
| GO:0050906 | detection of stimulus involved in sensory perception | 0.000 | 104 |
| GO:0004984 | olfactory receptor activity | 0.000 | 98 |
| GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | 0.000 | 98 |
| GO:0051606 | detection of stimulus | 0.000 | 105 |
| GO:0007608 | sensory perception of smell | 0.000 | 98 |
| GO:0004888 | transmembrane signaling receptor activity | 0.000 | 129 |
| GO:0038023 | signaling receptor activity | 0.000 | 135 |
| GO:0060089 | molecular transducer activity | 0.000 | 135 |
| GO:0007186 | G-protein coupled receptor signaling pathway | 0.000 | 127 |
| GO:0007600 | sensory perception | 0.000 | 115 |
| GO:0004871 | signal transducer activity | 0.000 | 136 |
| GO:0050877 | nervous system process | 0.000 | 119 |
| GO:0003008 | system process | 0.000 | 127 |
| GO:0016021 | integral component of membrane | 0.000 | 217 |
| GO:0031224 | intrinsic component of membrane | 0.000 | 219 |
| GO:0007165 | signal transduction | 0.000 | 173 |
| GO:0023052 | signaling | 0.000 | 178 |
| GO:0044425 | membrane part | 0.000 | 225 |
| GO:0007154 | cell communication | 0.000 | 179 |
| GO:0042221 | response to chemical | 0.000 | 167 |
| GO:0071944 | cell periphery | 0.000 | 174 |
| GO:0005886 | plasma membrane | 0.000 | 171 |
| GO:0032501 | multicellular organismal process | 0.000 | 214 |
| GO:0005549 | odorant binding | 0.000 | 25 |
| GO:0051716 | cellular response to stimulus | 0.000 | 193 |