Table 4.

Multivariable analysis immunoscore biopsy vs. clinical parameters for time to recurrence and overall survival.

		TTR Model (45/109) *			OS Model (39/108) *
	Variable	Hazard Ratio (95% CI)	p-Value 1	C-Index (95% CI)	Hazard Ratio (95% CI)	p-Value 1	C-Index (95% CI)
Multivariable Cox model stratified by center				0.7			0.73
				(0.61–0.8)			(0.64–0.82)
Immunoscore (3 groups)
	ISb-1 vs. ISb-0	0.24 (0.08–0.7)	0.0087		0.25 (0.09–0.71)	0.0087
	ISb-2 vs. ISb-0	0.38 (0.18–0.81)	0.0123		0.21 (0.08–0.51)	0.0006
Gender
	Female vs. male	1.37 (0.65–2.89)	0.4108		0.72 (0.29–1.77)	0.4716
Professional toxic exposure
	Yes vs. no	0.34 (0.07–1.63)	0.1754		0.79 (0.2–3.07)	0.7326
	Unkown vs. no	0.69 (0.21–2.21)	0.5296		0.62 (0.17–2.32)	0.4815
Histologic variant
	Variant vs. UC	0.6 (0.22–1.66)	0.3278		1.12 (0.42–2.97)	0.8251
	Unkown vs. UC	0 (0-Inf)	0.9977		-	-
T stage
	T3–4 vs. T2	2.8 (0.89–8.81)	0.0786		4.31 (1.04–17.76)	0.0434
	Unknown vs. T2	3.08 (0.68–13.94)	0.1444		0.69 (0.12–4)	0.6750
N stage
	N+ vs. N0	4.14 (0.95–18.07)	0.0587		1.91 (0.31–11.76)	0.4839
	Unknown vs. N0	1.48 (0.29–7.55)	0.6344		2.1 (0.37–12.06)	0.4044

* Events/total; ¹ stratified covariate Wald p-value by center.