Figure 2.

Cancer therapy-induced cell damage. IR, chemotherapy, as well as multikinase inhibitor-based therapies, induce widespread cell damage affecting proliferating tumor cells, stromal cells in the tumor microenvironment and normal cells in healthy tissues. This induces apoptosis or senescence and its associated SASP, that in turn amplifies senescence, recruits immune cells and modulates angiogenesis. Senolytic drugs may impact on cells (tumor or normal) response to SASP.