Physiological characteristics and lipopolysaccharide (LPS)-mediated inflammatory response in LysM-B2KO mice. (A) Targeting strategy for the conditional disruption of the Bscl2 gene in the myeloid lineage. (B) Bscl2 mRNA expression across different tissues and bone-marrow-derived macrophages (BMDM) of LysM-B2KO mice relative to the 18s gene. (C,D) Male and female body weight, (E,F) male and female fat mass, and (G,H) male and female glucose tolerance of LysM-B2KO mice at 24 weeks of age. Effect of LPS on the (I,J) body temperature and (K,L) serum glucose in male and female LysM-B2KO mice at 32 weeks of age (female n = 5–7, male n = 7–10). Data are represented as mean ± SEM, * p < 0.05, ** p < 0.01.