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. 2021 Jan 28;22(3):1319. doi: 10.3390/ijms22031319

Figure 5.

Figure 5

Immunohistochemical localization of caspase-1 in the testes from rats of sham, varicocele, varicocele contralateral, varicocele plus Se (0.4 mg/kg/day i.p.), varicocele plus Se contralateral, varicocele plus PDRN (8 mg/kg/day i.p.), varicocele contralateral plus PDRN, varicocele plus Se plus PDRN, varicocele contralateral plus Se plus PDRN groups. (A): In sham rats, no caspase-1 positive cells can be observed. (B): In varicocele rats, a large number of caspase-1 positive cells are located in the wall of the tubules (arrow). (C): In the contralateral testes of the same rats, some isolated caspase-1 positive cells are present (arrow). (D): In varicocele rats treated with Se, many caspase-1 positive cells are present in the periphery of the seminiferous tubules (arrow). (E): In the contralateral testes of the same group, some caspase-1 positive cells are located in the external part of the tubules (arrow). (F): In the testes of varicocele rats treated with PDRN, fewer caspase-1 positive cells are located along the periphery of the tubules (arrow). (G): In contralateral testes of the same group, only isolated caspase-1 positive cells (arrow) are present. (H,I): In the seminiferous tubules of both operated and contralateral testes of varicocele rats treated with Se plus PDRN, very rare or no caspase-1 positive cells are demonstrated. (Scale bar: 50 µm).