Table 3.
Effects on %TWAC (percentage of tubules with apoptotic cells), on the apoptotic index (mean number of TUNEL-positive cells per tubule), and on the number of caspase-1 positive cells/MF (microscopic field) as induced by Se (0.4 mg/kg i.p.), PDRN (8 mg/Kg/day i.p.) and Se (0.4 mg/kg i.p.) plus PDRN (8 mg/Kg/ day i.p.) in varicocele rats as compared to sham and varicocele rats. Se = seleno-L-methionine; PDRN = polydeoxyribonucleotide; CL = contralateral testis. All values are expressed as mean ± SE; n = 7 animals for each group. a p < 0.05 vs. sham; b p < 0.05 vs. varicocele.
| Groups | % TWAC | Apoptotic Index | Caspase-1 Positive Cells/MF |
|---|---|---|---|
| Sham | 0.2 ± 0.1 | 0.1 ± 0.1 | 0.3 ± 0.1 |
| Varicocele | 35 ± 5 a | 10 ± 2.6 a | 15.2 ± 4.1 a |
| Varicocele + CL | 7.5 ± 2.6 a,b | 4.1 ± 1.4 a,b | 7.5 ± 2.1 a,b |
| Varicocele + Se | 13.2 ± 2.7 a,b | 7.1 ± 1.4 a,b | 6.3 ± 1.7 a,b |
| Varicocele + Se CL | 3.3 ± 1.3 a,b | 3.9 ± 1.2 a,b | 3.5 ± 1.3 a,b |
| Varicocele + PDRN | 7.2 ± 1.7 a,b | 5.3 ± 1.1 a,b | 5.1 ± 1.6 a,b |
| Varicocele + PDRN CL | 1.8 ± 0.4 b | 2.2 ± 0.5 b | 2.1 ± 0.7 b |
| Varicocele + PDRN + Se | 4.4 ± 0.8 b | 1.5 ± 0.6 b | 1.3 ± 0.3 b |
| Varicocele + PDRN + Se CL | 1.3 ± 0.2 b | 0.2 ± 0.1 b | 0.4 ± 0.1 b |