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. 2021 Jan 28;22(3):1299. doi: 10.3390/ijms22031299

Figure 5.

Figure 5

Alterations of estrous cycles in STZ-treated mice. (A) Estrous cycle stage classification of each group during 14 days in wild-type (WT, white diamonds); control (CON, black diamonds); 15 mg/kg streptozotocin (STZ-15, bright orange rectangles); 30 mg/kg streptozotocin (STZ-30, dark orange triangles); and 60 mg/kg streptozotocin (STZ-60, red circles) groups. Treatment with STZ injections disrupted ovarian functions. (B) The number of normal estrous cycles in each group during 2 weeks in CON, black bar; STZ-15, orange bar; STZ-30, dashed orange bar; and STZ-60, red bar, groups. (C) The number of each estrous cycle (%) stage during 14 days indicating that STZ injections alter regular ovary functions in mice. E, Estrus; P, Proestrus; M/D, Metestrus or diestrus.