Time-dependent uptake of FITC-labeled HA − PTX + RTV − NMF solution and FITC-labeled PTX + RTV − NMF solution in breast cancer MCF-7 and triple-negative breast cancer, MDA-MB-231 cells. (A) Uptake of FITC-labeled HA − PTX + RTV − NMF solution and FITC-labeled PTX + RTV − NMF solution at 3, 6, 12, and 24 h in MCF-7 cells, (B) uptake of FITC-labeled HA − PTX + RTV − NMF solution and FITC-labeled PTX + RTV − NMF solution at 3, 6, 12, and 24 h in MDA-MB-231 cells. (C) Uptake of FITC-labeled HA − PTX + RTV − NMF solution and FITC-labeled PTX + RTV − NMF solution at 3, 6, 12, and 24 h in MCF-12A cells. The data were expressed as mean ± SD (n = 3). (# = significant difference as compared to control group and * p ≤ 0.05, ** p ≤ 0.01, ns = not significant as compared to PTX + RTV − NMF group).