Table 2.
Full factorial design of experiment using JMP software.
| Formulation | Pattern | Sonication Time (min) | HA−PLGA (wt%) | Vit E TPGS(wt%) |
Size (nm) |
PDI | Zeta (mV) |
PTX | RTV | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| EE% | LE% | EE% | LE% | ||||||||
| F1 | (0)(0)(0) | 22.5 | 2 | 4 | 144.0 | 0.2 | 0.2 | 96.5 | 7.4 | 95.5 | 1.9 |
| F2 | (0)(0)(0) | 22.5 | 2 | 4 | 146.0 | 0.2 | 0.2 | 95.7 | 7.2 | 96.9 | 1.8 |
| F3 | (−)(−)(+) | 20 | 0.5 | 5 | 168.8 | 0.5 | 0.0 | 83.0 | 6.9 | 84.2 | 1.9 |
| F4 | (−)(+)(+) | 20 | 3.5 | 5 | 256.2 | 0.6 | 0.0 | 88.9 | 4.9 | 90.0 | 1.3 |
| F5 | (0)(0)(0) | 22.5 | 2 | 4 | 142.5 | 0.2 | 0.1 | 95.4 | 7.2 | 96.0 | 1.8 |
| F6 | (+)(−)(+) | 25 | 0.5 | 5 | 159.6 | 0.8 | 0.2 | 85.8 | 7.1 | 86.7 | 1.6 |
| F7 | (+)(−)(−) | 25 | 0.5 | 3 | 204.3 | 0.3 | 0.0 | 73.7 | 9.2 | 93.8 | 3.2 |
| F8 | (−)(−)(−) | 20 | 0.5 | 3 | 179.7 | 0.3 | 0.0 | 74.0 | 9.3 | 93.4 | 3.2 |
| F9 | (+)(+)(+) | 25 | 3.5 | 5 | 189.9 | 0.6 | 0.0 | 88.4 | 5.0 | 89.2 | 1.3 |
| F10 | (−)(+)(−) | 20 | 3.5 | 3 | 249.8 | 0.5 | 0.2 | 76.9 | 5.5 | 78.7 | 1.5 |
| F11 | (+)(+)(−) | 20 | 3.5 | 3 | 225.0 | 0.4 | 0.2 | 75.5 | 5.4 | 75.9 | 1.4 |