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. 2021 Jan 26;26(3):640. doi: 10.3390/molecules26030640

Figure 6.

Figure 6

The involvement of Yes-associated protein (YAP) in the regulatory effect of kahweol in Ang II-stimulated VSMCs. (A,B) Cells were pretreated with rCTGF and kahweol at one hour intervals and then stimulated with Ang II for 24 h. Protein levels of YAP and β-actin were determined by Western blotting with specific antibodies. Bar graphs present the densitometric quantification of the Western blot bands. (C) Cells were pretreated with verteporfin (100 nM) for one hour and then treated with Ang II (100 nM) for 24 h. Protein levels of phosphorylated FAK, YAP, CTGF and β-actin were determined by Western blotting with specific antibodies. Bar graphs present the densitometric quantification of the Western blot bands. Results are representative of three independent experiments. *, p < 0.05 vs. untreated control; #, p < 0.05 vs. Ang II group; §, p < 0.05 vs. kahweol + Ang II treated group.