AATD	alpha1-antitrypsin deficiency
EL-NE	elastin degradation mediated by NE
PR3	proteinase 3
NE	Neutrophil elastase
AAT	alpha1-antitrypsin
GPA	polyangiitis
COPD	chronic obstructive pulmonary disease
RCL	Reactive centre loop
SNPs	single-nucleotide polymorphisms
FEV1	forced expiratory volume in one second
RCT	randomised controlled clinical trial