Table 1.

NE and/or PR3 specific inhibitors and their properties.

Inhibitor	Specificity	Permeability	NE Ki (nM)
ONO-5046	NE and PR3	Non-cell permeable	200 ± 20
ONO-6818	NE	Non-cell permeable	12.16
AZD9668	NE	Unknown	9.4
BAY-678	NE, PR3 unknown	Unknown	15
BAY 85-8501	NE, PR3 unknown	Unknown	0.08
DMP-777	NE and PR3	Cell permeable	Kinac/Ki = 3800.000 M−1 s−1
GW-311616	NE, PR3 unknown	Cell permeable	0.31

NE; neutrophil elastase; PR3: proteinase 3; K_i: inhibition constant; K_inac: inactivation rate constant.