Table 1.

Effect of TP53 on different DNA repair pathways; BER—base excision repair; NER—nucleotide excision repair; HR—homologous recombination; wt—wild-type.

TP53 Status	DNA Repair Pathway	Effect on DNA Repair	Citation
TP53 missense mutation	BER	APE1 regulation	[41]
Hot-spot tumor-derived TP53 mutants	BER	Does not enhance activity of repair pathway in comparison with wt p53	[39]
Arg273His mutant TP53	NER	Does not inhibit XPD (Rad3) and XPB DNA helicase activities in comparison with wt p53	[47]
p53 knock out	NER	Increase in chromosomal abnormalities	[48]
R248W and R273H mutant TP53	HR	Interaction with MRE11; inter-chromosomal translocations	[50]