Table 3.

Topological network characteristics of cancer (Ca) and control (Co) metabolite association networks across cancer types. Sample origin is labeled as T, U, S, P for tissue, urine, serum, and plasma, respectively. MM is multiple myeloma and data set identifiers are noted as: * ST000054, ^§ ST000221, ^# ST000390 and ^† ST000396. Topological measures in the column names are: N = Nodes, E = Edges, Mean Conn. = Mean Connectivity, Mean Deg. = Mean Degree, Mean Close. = Mean Closeness, Mean Betw. = Mean Betweenness, D = Diameter, Mean Min. Dist. = Mean Minimal Distance, Mean Page Rank, Hub N = Hub Nodes, Centr. = Centralization, and Trans. = Transivity. All topological measures are further explained in the material and methods.

Network	N	E	Mean Conn.	Mean Deg.	Mean Close.	Mean Betw.	D	Mean Min. Dist.	Mean Page Rank	Hub N	Centr.	Trans.
Ca Renal (U) [21]	203	1939	0.407	0.095	0.348	0.009	6	2.886	0.005	95	0.163	0.191
Co Renal (U) [21]	203	1889	0.435	0.092	0.344	0.010	5	2.920	0.005	100	0.225	0.195
Ca Liver (S) [19]	62	229	0.547	0.121	0.205	0.067	11	5.003	0.016	43	0.207	0.036
Co Liver (S) [19]	62	191	0.428	0.101	0.051	0.036	11	4.489	0.016	40	0.129	0.025
Ca Liver (U) [19]	77	357	0.373	0.122	0.081	0.028	9	3.588	0.013	46	0.220	0.247
Co Liver (U) [19]	77	289	0.355	0.099	0.076	0.036	10	4.394	0.013	40	0.164	0.149
Ca Lung (T) [20]	91	632	0.272	0.154	0.152	0.026	8	3.484	0.011	14	0.223	0.457
Co Lung (T) [20]	91	612	0.263	0.149	0.135	0.023	8	3.239	0.011	15	0.295	0.372
Ca Prostate (T) [20]	72	294	0.168	0.115	0.052	0.045	16	5.513	0.014	9	0.167	0.447
Co Prostate (T) [20]	72	276	0.148	0.108	0.065	0.049	12	5.493	0.014	21	0.117	0.482
Ca Gastric (P) [18]	103	10204	2.072	1.943	0.243	0.000	1	1.000	0.010	0	2.018	1.000
Co Gastric (P) [18]	103	10004	2.225	1.904	0.193	0.000	1	1.000	0.010	0	2.017	1.000
Ca Breast (P) [16]	68	585	1.094	0.257	0.436	0.020	4	2.307	0.015	39	0.131	0.157
Co Breast (P) [16]	68	637	1.078	0.280	0.449	0.019	4	2.238	0.015	28	0.168	0.185
Ca Breast (T) *	65	499	0.566	0.240	0.370	0.028	5	2.750	0.015	8	0.229	0.334
Co Breast (T) *	65	293	0.409	0.141	0.106	0.042	10	4.130	0.015	23	0.234	0.397
Ca MM (T) §	191	3171	0.233	0.175	0.334	0.011	6	3.073	0.005	13	0.404	0.613
Co MM (T) §	191	2807	0.217	0.155	0.328	0.011	6	3.065	0.005	1	0.151	0.506
Ca Colorectal (S) [17]	113	813	0.650	0.128	0.347	0.017	6	2.911	0.009	59	0.122	0.169
Co Colorectal (S) [17]	113	713	0.710	0.113	0.327	0.019	7	3.100	0.009	69	0.084	0.141
Ca Breast (P) [15]	221	2863	0.941	0.118	0.389	0.007	4	2.585	0.005	78	0.146	0.215
Co Breast (P) [15]	221	2857	0.853	0.118	0.389	0.007	5	2.581	0.005	78	0.110	0.224
Ca Breast (S) [15]	260	3778	0.667	0.112	0.390	0.006	5	2.581	0.004	89	0.228	0.215
Co Breast (S) [15]	260	3500	0.463	0.104	0.377	0.006	6	2.675	0.004	69	0.143	0.233
Ca Lung (T) #	182	1614	0.732	0.098	0.261	0.010	5	2.831	0.005	123	0.101	0.153
Co Lung (T) #	182	2116	0.274	0.128	0.258	0.010	6	2.885	0.005	19	0.225	0.398
Ca Lung (P) †	126	878	0.460	0.111	0.247	0.016	7	3.055	0.008	62	0.113	0.189
Co Lung (P) †	126	914	0.833	0.116	0.169	0.014	5	2.844	0.008	98	0.140	0.110