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. 2021 Jan 24;22(3):1133. doi: 10.3390/ijms22031133

Figure 1.

Figure 1

Human representative of IGFBP2 genetic and molecular structure. (A) Human representative of genetic structure of IGFBP2. There are three regulatory elements, ranging from distal, middle to proximal elements. The structure gene contains four exons and three introns. The product is a mature mRNA of 1414 pb. (B) Human representative structure of IGFBP2 protein domain for the mature protein of 289 amino acids residues. There are three principal domains. The N-terminal domain, the middle domain or the middle region and the C-terminal domain. The N- (extracted from Galea C. et al. [9]) and C-terminal (PDB: 2H7T for the C-domain of IGFBP2) domain are presented. Both N- and C-terminal domains contain IGF binding sites, which suggests that these domains are highly conserved. However, the middle region has a proteolytic cleavage and phosphorylation sites, which indicates that this domain may be implicated in the regulation of bioavailability of IGF1 and stability of the protein structure.