Table 6.
Inhibitory activity towards the beta-hexosaminidase release of P. amarus extract and its compounds.
| Concentration | 1.25 µg/mL | 2.5 µg/mL | 5 µg/mL | 10 µg/mL | 25 µg/mL | 50 µg/mL |
|---|---|---|---|---|---|---|
| Ketotifen fumarate (positive control) |
- | - | 17.71 ± 1.05 | 22.23 ± 0.75 *** | 27.43 ± 0.58 *** | - |
| P. amarus | - | - | 6.14 ± 3.82 | 9.88 ± 5.22 | 11.80 ± 5.62 | - |
| Phyllanthin (1) | - | 26.35 ± 3.18 * | 37.93 ± 6.51 ** | 38.40 ± 8.72 ** | - | - |
| Hypophyllanthin (2) | 23.94 ± 3.31 ** | 32.33 ± 4.99 *** | 32.32 ± 4.51 *** | - | - | - |
| Niranthin (3) | - | - | - | 29.29 ± 5.81 * | 31.28 ± 7.43 * | 32.09 ± 7.27 * |
| Corilagin (4) | - | - | - | 2.43 ± 3.26 | 5.12 ± 2.09 | 6.68 ± 1.71 |
Data are presented as mean ± standard error of mean (SEM) (n = 3) with significant value of * p < 0.05, ** p < 0.01, *** p < 0.001 as compared to normal.