Table 7.
Inhibitory activity towards histamine release of P. amarus extract and its compounds.
| Concentration | 1.25 µg/mL | 2.5 µg/mL | 5 µg/mL | 10 µg/mL | 25 µg/mL |
|---|---|---|---|---|---|
| Ketotifen fumarate (positive control) |
- | - | 3.90 ± 6.80 | 44.74 ± 23.01 | 58.74 ± 23.16 |
| P. amarus | - | 40.26 ± 27.12 | 11.22 ± 28.00 | −6.99 ± 36.16 | - |
| Phyllanthin (1) | - | −3.05 ± 7.93 | 55.80 ± 19.31 | −11.64 ± 70.80 | - |
| Hypophyllanthin (2) | 16.39 ± 46.64 | 11.89 ± 64.33 | 71.20 ± 34.68 | - | - |
| Niranthin (3) | - | - | 34.74 ± 12.17 | 58.96 ± 22.24 | 41.22 ± 31.24 |
| Corilagin (4) | nd | nd | nd | nd | nd |
Data are presented as mean ± SEM (n = 3). nd: not defined.