Table 7.

Multivariable regression of APOE-ɛ4 status and neuroanatomic volume and thickness per ROI.

ROI	Comparison Groups
	APOE-ɛ4(−) vs. APOE-ɛ44(+)
	B	SE	p-Value	R2
Total ICV	−13698	23822	0.57	0.312
Total gray volume	−1932.9	5208.5	0.71	0.825
Cortex volume	−1125.3	4541.6	0.81	0.773
L Accumbens area	22.527	19.780	0.26	0.428
R Accumbens area	−24.698	19.020	0.20	0.382
L Amygdala	−6.604	33.963	0.85	0.334
R Amygdala	12.443	42.132	0.77	0.185
Brain Stem	−710.59	306.40	0.02	0.512
L Caudate	95.763	77.147	0.22	0.468
R Caudate	135.66	83.163	0.11	0.492
L Hippocampus	−91.780	74.287	0.22	0.434
R Hippocampus	9.805	67.792	0.89	0.399
L Putamen	−143.81	124.25	0.25	0.516
R Putamen	−53.235	97.863	0.59	0.606
Left Thalamus	34.182	170.03	0.84	0.384
Right Thalamus	−25.139	125.03	0.84	0.475
CC-posterior	5.094	25.748	0.84	0.239
CC-mid-poster	−30.256	16.590	0.07	0.089
CC-central	−22.641	14.790	0.13	0.084
CC-mid-anterior	−12.932	15.477	0.41	0.157
CC-anterior	−7.022	24.002	0.77	0.216
L Pallidum	−56.903	47.265	0.24	0.317
R Pallidum	−6.0494	41.844	0.15	0.402
L lateral Ventricle	1669.5	945.24	0.08	0.287
R lateral Ventricle	555.08	933.86	0.55	0.246
L hemisphere, mean thick	0.006	0.019	0.75	0.304
R hemisphere, mean thick	0.005	0.018	0.80	0.279
L frontal thick	−0.007	0.020	0.73	0.395
R frontal thick	0.001	0.019	0.95	0.266
L temporal thick	0.011	0.024	0.63	0.257
R temporal thick	0.008	0.024	0.73	0.235
L parietal thick	−0.005	0.022	0.81	0.241
R parietal thick	−0.001	0.023	0.96	0.208
L cingulate thick	0.024	0.027	0.37	0.424
R cingulate thick	−0.029	0.028	0.30	0.351
L occipital thick	0.004	0.019	0.82	0.129
R occipital thick	0.002	0.020	0.94	0.129
L insula thick	−0.004	0.026	0.89	0.266
R insula thick	−0.007	0.028	0.81	0.231

Adjusted for total intracranial volume, sex, age, and head coil for volumes and adjusted for sex, age, and head coil for thickness. Abbreviations: L = left, R = right, CC = corpus callosum, Thick = thickness.