Table 8.
Multivariable regression of APOE-ɛ4 status and DTI (fractional anisotropy (FA) and mean diffusivity (MD)).
| ROI | Comparison Groups | |||
|---|---|---|---|---|
| APOE-ɛ4(−) vs. APOE-ɛ4(+) | ||||
| B | SE | p-Value | R2 | |
| FA-ATR L | 0.003 | 0.003 | 0.38 | 0.257 |
| FA-ATR R | 0.003 | 0.003 | 0.32 | 0.253 |
| FA-CG L | 0.001 | 0.004 | 0.87 | 0.317 |
| FA-CG R | 0.000 | 0.004 | 0.93 | 0.200 |
| FA-CING L | −0.011 | 0.005 | 0.03 | 0.214 |
| FA-CING R | −0.011 | 0.004 | 0.01 | 0.222 |
| FA-CST L | 0.001 | 0.003 | 0.83 | 0.253 |
| FA-CST R | −0.002 | 0.003 | 0.61 | 0.289 |
| FA-FMAJ | 0.002 | 0.003 | 0.59 | 0.244 |
| FA-FMIN | 0.004 | 0.004 | 0.26 | 0.430 |
| FA-IFOF L | 0.001 | 0.003 | 0.68 | 0.382 |
| FA-IFOF R | 0.004 | 0.003 | 0.24 | 0.315 |
| FA-ILF L | −0.001 | 0.003 | 0.79 | 0.348 |
| FA-ILF R | −0.001 | 0.003 | 0.86 | 0.274 |
| FA-SLF L | 0.002 | 0.003 | 0.44 | 0.296 |
| FA-SLF R | 0.002 | 0.003 | 0.41 | 0.328 |
| FA-SLFT L | 0.000 | 0.004 | 0.95 | 0.148 |
| FA-SLFT R | 0.002 | 0.003 | 0.60 | 0.277 |
| FA-UF L | 0.002 | 0.003 | 0.54 | 0.209 |
| FA-UF R | 0.004 | 0.003 | 0.18 | 0.206 |
| FA-CCBody | −0.005 | 0.006 | 0.41 | 0.249 |
| FA-CCGenu | 0.004 | 0.005 | 0.41 | 0.346 |
| FA-CCSplenium | 0.002 | 0.004 | 0.64 | 0.196 |
| FA-ws | 0.001 | 0.003 | 0.68 | 0.351 |
| MD-ATR L | 7.319 × 10−6 | 0.000 | 0.24 | 0.133 |
| MD-ATR R | 3.674 × 10−6 | 0.000 | 0.62 | 0.100 |
| MD-CG L | 8.128 × 10−8 | 0.000 | 0.99 | 0.033 |
| MD-CG R | −1.644 × 10−6 | 0.000 | 0.72 | 0.039 |
| MD-CING L | 1.377 × 10−5 | 0.000 | 0.08 | 0.215 |
| MD-CING R | 7.395 × 10−6 | 0.000 | 0.38 | 0.117 |
| MD-CST L | 4.134 × 10−6 | 0.000 | 0.36 | 0.132 |
| MD-CST R | 5.745 × 10−6 | 0.000 | 0.25 | 0.151 |
| MD-FMAJ | 1.775 × 10−7 | 0.000 | 0.97 | 0.362 |
| MD-FMIN | −2.931 × 10−6 | 0.000 | 0.66 | 0.191 |
| MD-IFOF L | −2.129 × 10−6 | 0.000 | 0.66 | 0.063 |
| MD-IFOF R | −5.288 × 10−6 | 0.000 | 0.29 | 0.100 |
| MD-ILF L | −2.673 × 10−6 | 0.000 | 0.60 | 0.060 |
| MD-ILF R | −5.404 × 10−6 | 0.000 | 0.29 | 0.066 |
| MD-SLF L | −7.339 × 10−7 | 0.000 | 0.86 | 0.029 |
| MD-SLF R | −1.968 × 10−6 | 0.000 | 0.65 | 0.051 |
| MD-SLFT L | −2.722 × 10−6 | 0.000 | 0.58 | 0.042 |
| MD-SLFT R | −5.847 × 10−6 | 0.000 | 0.29 | 0.154 |
| MD-UF L | −4.273 × 10−6 | 0.000 | 0.43 | 0.266 |
| MD-UF R | −2.661 × 10−6 | 0.000 | 0.64 | 0.207 |
| MD-CCBody | 5.241 × 10−6 | 0.000 | 0.46 | 0.100 |
| MD-CCGenu | −2.526 × 10−8 | 0.000 | 0.99 | 0.159 |
| MD-CCSplenium | 2.404 × 10−6 | 0.000 | 0.70 | 0.213 |
| MD-ws | 2.734 × 10−7 | 0.000 | 0.95 | 0.041 |
Adjusted for age, sex, and head coil. Abbreviations: fractional anisotropy (FA), mean diffusivity (MD), anterior thalamic radiation (ATR), cingulum (cingulate gyrus, CG), cingulum (hippocampus, CING), corticospinal tract (CST), forceps major (FMAJ), forceps minor (FMIN), inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus (SLF), superior longitudinal fasciculus (temporal part, SLFT), uncinate fasciculus (UF), corpus callosum (CC), whole skeleton (ws).