Figure 1.

Response of MPC^wt spheroids to single-dose external X-ray irradiation; diameter at treatment start: 616 ± 2 µm (MPC^wt); (A) changes in spheroid diameters in response to increasing irradiation doses; (B) spheroid re-growth proportions in treatment groups exposed to increasing irradiation doses; (C) short-term effects of irradiation at increasing doses presented as changes in relative spheroid growth (%SG, 0–6 days after irradiation), categorized into different growth scenarios and visualized as growth arrest dose (GAD); (D) long-term effects of irradiation at increasing doses presented as spheroid control probabilities (%SCP, 35 days after irradiation) and visualized as half-maximal spheroid control dose (SCD₅₀).