Table 3.
Diagnostic performance of six biomarkers overlapping between PEA and QMA measurements for detecting CRC cases from participants in screening colonoscopy.
| Marker | Pearson’s Correlation Coefficient |
PEA Measurements | QMA Measurements | DeLong p-value for AUC Testing |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC (95% CI) |
p-value | p-value adj | Se% at 80% Sp | Se% at 90% Sp | AUC (95% CI) |
p-value | p-value adj | Se% at 80% Sp | Se% at 90% Sp | |||
| AREG | 0.06 | 0.72 (0.64–0.81) |
<0.01 ** | <0.01 ** | 57 | 39 | 0.60 (0.51–0.70) |
<0.05 * | 0.10 | 32 | 20 | 0.06 |
| CEA | 0.18 | 0.71 (0.62–0.80) |
<0.01 ** | <0.01 ** | 63 | 43 | 0.54 (0.45–0.64) |
0.38 | 0.46 | 27 | 20 | <0.05 * |
| FASLG | −0.03 | 0.48 (0.39–0.58) |
0.75 | 0.75 | 27 | 20 | 0.53 (0.44–0.62) |
0.55 | 0.55 | 20 | 13 | 0.49 |
| GDF15 | 0.69 | 0.64 (0.55–0.73) |
<0.01 ** | <0.05 * | 34 | 27 | 0.63 (0.54–0.72) |
<0.05 * | <0.05 * | 41 | 16 | 0.84 |
| KRT19 | 0.42 | 0.72 (0.63–0.80) |
<0.01 ** | <0.01 ** | 52 | 38 | 0.57 (0.47–0.66) |
0.16 | 0.31 | 29 | 20 | <0.05 * |
| OPN | 0.18 | 0.63 (0.54–0.72) |
<0.01 ** | <0.05 * | 38 | 23 | 0.56 (0.47–0.66) |
0.20 | 0.31 | 27 | 13 | 0.25 |
Abbreviations: AUC, area under the receiver operating curve; CRC, colorectal cancer; 95% CI, 95% confidence interval; PEA, proximity extension assay; p-value, apparent p-values without any adjustments; p-value adj, p-value after adjustment for multiple testing by the Benjamini–Hochberg method; QMA, quantibody microarray; Se, sensitivity; Sp, specificity. Protein abbreviations: AREG, amphiregulin; CEA, carcinoembryonic antigen; FASLG, Fas ligand; GDF15, growth differentiation factor 15; KRT19, keratin Type I cytoskeletal 19; OPN, osteopontin. Note: *, Significant at a p-value of < 0.05; **, significant at a p-value of < 0.01.