Table 4.
Diagnostic performance for 11 out of 35 biomarkers overlapping from PEA and IpA measurements for detecting CRC cases from participants in screening colonoscopy.
| Marker | Pearson’s Correlation Coefficient |
PEA Measurements | IpA Measurements | DeLong p-value for AUC Testing |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC (95% CI) |
p-value | p-value adj | Se % at 80% Sp |
Se % at 90% Sp |
AUC (95% CI) |
p-value | p-value adj | Se % at 80% Sp |
Se % at 90% Sp |
|||
| AREG | 0.02 | 0.71 (0.57–0.84) |
<0.01 ** | 0.07 | 45 | 28 | 0.53 (0.38–0.68) |
0.71 | 0.85 | 19 | 10 | 0.09 |
| CHI3L1 | −0.04 | 0.61 (0.46–0.76) |
0.15 | 0.56 | 26 | 17 | 0.58 (0.44–0.73) |
0.27 | 0.79 | 15 | 7 | 0.07 |
| CTSD | 0.06 | 0.75 (0.63–0.88) |
<0.01 ** | <0.05 * | 55 | 35 | 0.54 (0.39–0.69) |
0.61 | 0.79 | 14 | 6 | <0.01 ** |
| GAL1 | 0.22 | 0.62 (0.48–0.77) |
0.11 | 0.53 | 23 | 9 | 0.56 (0.41–0.71) |
0.43 | 0.79 | 13 | 6 | 0.56 |
| GDF15 | 0.00 | 0.64 (0.50–0.79) |
0.06 | 0.40 | 31 | 18 | 0.54 (0.39–0.69) |
0.56 | 0.79 | 14 | 6 | 0.08 |
| KRT19 | 0.01 | 0.74 (0.61–0.86) |
<0.01 ** | <0.05 * | 47 | 37 | 0.57 (0.42–0.72) |
0.34 | 0.79 | 15 | 9 | 0.10 |
| MMP2 | −0.08 | 0.61 (0.46–0.75) |
0.15 | 0.56 | 23 | 12 | 0.55 (0.40–0.70) |
0.51 | 0.79 | 13 | 6 | 0.14 |
| OPG | 0.00 | 0.65 (0.51–0.80) |
<0.05 * | 0.33 | 41 | 32 | 0.54 (0.39–0.69) |
0.63 | 0.79 | 16 | 8 | 0.07 |
| PSIP1 | 0.11 | 0.62 (0.47–0.76) |
0.12 | 0.53 | 18 | 7 | 0.58 (0.43–0.73) |
0.31 | 0.79 | 17 | 8 | 0.07 |
| TR | −0.24 | 0.68 (0.55–0.82) |
<0.01 ** | 0.14 | 33 | 26 | 0.59 (0.45–0.74) |
0.22 | 0.79 | 15 | 7 | <0.01 ** |
| VIM | 0.12 | 0.63 (0.49–0.78) |
0.08 | 0.47 | 28 | 10 | 0.55 (0.40–0.70) |
0.49 | 0.81 | 36 | 13 | 0.45 |
Abbreviations: AUC, area under the receiver operating curve; CRC, colorectal cancer; 95% CI, 95% confidence interval; IpA, immunome protein array; PEA, proximity extension assay; p-value, apparent p-values without any adjustments; p-value adj, p-value after adjustment for multiple testing by the Benjamini–Hochberg method; Se, sensitivity; Sp, specificity. Protein abbreviations: AREG, amphiregulin; CHI3L1, chitinase-3-like protein 1; CTSD, cathepsin D; GAL1, galectin-1; GDF15, growth differentiation factor 15; KRT19, keratin Type I cytoskeletal 19; MMP2, matrix metalloproteinase-2; OPG, osteoprotegerin; PSIP1, PC4 and SFRS1-interacting protein; TR, transferrin receptor protein 1; VIM, vimentin. Note: *, Significant at a p-value of < 0.05; **, significant at a p-value of < 0.01.