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In vitro cytotoxicity of PSMA-1-MMAE, MMAE, and PSMA-ADC.
| Cells | PSMA-1-VcMMAE (EC50, nM) |
PSMA-1-VcMMAE + PSMA-1 (EC50, nM) |
PSMA-1-VcMMAE + E64 (EC50, nM) |
MMAE (EC50, nM) |
PSMA-ADC (EC50, nM) |
|---|---|---|---|---|---|
| PC3pip | 4.64 ± 0.83 | 241.1 ± 8.6 | 31.09 ± 2.11 | 0.24 ± 0.05 | 0.063 ± 0.003 |
| PC3flu | 221.7 ± 2.8 | 261.3 ± 5.6 | 384.9 ± 5.3 | 0.21 ± 0.04 | 241.8 ± 9.3 |
