Table 1.
Significantly enriched metabolic pathways identified in the gene set enrichment analysis (GSEA) for the GSE61629 transcriptomic study.
| Comparison | Pathway Name | KEGG ID | LOR | p-Value | BY Adjusted |
|---|---|---|---|---|---|
| ET vs. HC | Oxidative phosphorylation | hsa00190 | −0.4946 | 7.57 × 10−8 | 3.24 × 10−5 |
| Citrate cycle (TCA cycle) | hsa00020 | −0.6648 | 1.87 × 10−4 | 4.00 × 10−2 | |
| alpha-linolenic acid metabolism | hsa00592 | 0.7378 | 3.18 × 10−4 | 4.53 × 10−2 | |
| PV vs. HC | Citrate cycle (TCA cycle) | hsa00020 | −0.9519 | 1.85 × 10−8 | 7.88 × 10−6 |
| Oxidative phosphorylation | hsa00190 | −0.4006 | 1.14 × 10−5 | 1.76 × 10−3 | |
| Carbon metabolism | hsa01200 | −0.4138 | 1.24 × 10−5 | 1.76 × 10−3 | |
| Valine, leucine and isoleucine degradation | hsa00280 | −0.6365 | 2.36 × 10−5 | 2.52 × 10−3 | |
| Starch and sucrose metabolism | hsa00500 | 0.6765 | 1.05 × 10−4 | 8.95 × 10−3 | |
| Propanoate metabolism | hsa00640 | −0.6678 | 1.48 × 10−4 | 1.06 × 10−2 | |
| Pyruvate metabolism | hsa00620 | −0.5943 | 4.15 × 10−4 | 2.53 × 10−2 | |
| PV vs. ET | − | − | − | − | − |
BY: Benjamini–Yekutieli, ET: essential thrombocythemia, HC: healthy control, PV: polycythemia vera, ST: secondary thrombocythemia, TCA cycle: tricarboxylic acid cycle.