Table 1.
Clinical and Biological Characteristics of the 11 Myelodysplastic Syndrome MDS Patients for Whom MDS-Likelihood Score (LS) Would Have Triggered Blood Smear Review, While Complete Blood Count (CBC) Did Not Generate Any Conventional Flag.
| Characteristics | #7 | #17 | #30 | #35 | #197 | #199 | #244 | #245 | #249 | #253 | #256 | Flag |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age | 86 | 71 | 82 | 90 | 90 | 68 | 79 | 83 | 89 | 86 | 77 | |
| Gender | F | F | M | F | M | M | F | M | M | F | F | |
| MDS groups | MDS-SLD | MDS-EB-1 | MDS-MLD | MDS-RS-SLD | MDS-SLD | MDS-SLD | MDS-RS-MLD | MDS-MLD | MDS-SLD | MDS-MLD | Del(5q) | |
| Delay from diagnosis (months) | 0 | 1 | 5 | 60 | 1 | 0 | 6 | NA | 0 | 0 | 0 | |
| Cytogenetics | normal | normal | normal | normal | tri15 | normal | del(11q), tri8 | NA | normal | normal | del(5q) | |
| IPPS-R | 1 | 3 | 2 | 2 | 4 | 2 | 4.5 | NA | 2.5 | 1 | 2 | |
| RCC (<120 days) | N | N | N | Y | N | N | Y | NA | Y | N | Y | |
| Growth factors | N | N | N | N | N | N | N | NA | N | N | N | |
| Other treatment | N | N | N | N | N | N | N | NA | N | N | N | |
| RBC (T/L) | 3.6 | 3.2 | 2.8 | 2.6 | 2.3 | 2.7 | 3.3 | 4.4 | 2.9 | 3.8 | 3.5 | |
| Hb (g/L) | 104 | 109 | 82 | 81 | 82 | 87 | 100 | 130 | 96 | 114 | 113 | <80 |
| Hct (%) | 31.2 | 32.0 | 25.1 | 24.3 | 23.9 | 27.3 | 30.9 | 38.7 | 28.4 | 34.9 | 34.5 | |
| MCV (fL) | 85.8 | 100.6 | 90.9 | 93.1 | 102.2 | 101.2 | 93.0 | 87.4 | 97.9 | 92.6 | 99.0 | >105 |
| MCH (pg/cell) | 28.6 | 34.3 | 29.9 | 31.0 | 35.0 | 32.3 | 30.1 | 29.2 | 33.0 | 30.3 | 32.4 | |
| MCHC (g/dL) | 33.3 | 34.1 | 32.8 | 33.3 | 34.3 | 31.9 | 32.4 | 33.5 | 33.7 | 32.7 | 32.7 | >36.0 |
| RDW (%) | 14.6 | 15.0 | 17.8 | 16.6 | 15.8 | 16.9 | 18.9 | 15.4 | 22.0 | 14.3 | 20.1 | >22.0 |
| Plt (G/L) | 227 | 146 | 394 | 373 | 111 | 383 | 182 | 104 | 188 | 257 | 447 | <100 |
| MPV (fL) | 9.3 | 11.3 | 8.8 | 9.4 | 8.5 | 7.8 | 10.7 | 10.8 | 8.6 | 8.6 | 10.7 | <7.0 |
| WBC(G/L) | 5.7 | 7.4 | 8.4 | 8.4 | 3.9 | 8.2 | 5.5 | 5.3 | 9.6 | 4.5 | 2.8 | |
| % NE | 67.5 | 83.4 | 79.0 | 74.8 | 78.7 | 79.0 | 61.4 | 76.5 | 79.8 | 46.0 | 52.6 | |
| % LY | 20.9 | 7.4 | 15.1 | 10.0 | 11.6 | 10.7 | 22.7 | 8.5 | 6.0 | 39.9 | 30.9 | |
| % MO | 8.2 | 8.3 | 3.4 | 10.4 | 6.9 | 7.1 | 10.7 | 12.8 | 11.2 | 10.2 | 9.4 | >20.0 |
| % EO | 2.4 | 0.4 | 1.3 | 2.5 | 2.3 | 2.6 | 4.2 | 1.6 | 1.9 | 3.5 | 4.1 | |
| % BA | 1.0 | 0.5 | 1.2 | 2.3 | 0.5 | 0.6 | 1.0 | 0.6 | 1.1 | 0.4 | 3.0 | |
| Abs NE (G/L) | 3.8 | 6.2 | 6.6 | 6.3 | 3.1 | 6.5 | 3.4 | 4.0 | 7.7 | 2.1 | 1.5 | <1.5 |
| Abs LY (G/L) | 1.2 | 0.5 | 1.3 | 0.8 | 0.5 | 0.9 | 1.3 | 0.5 | 0.6 | 1.8 | 0.9 | >4.0 |
| Abs MO (G/L) | 0.5 | 0.6 | 0.3 | 0.9 | 0.3 | 0.6 | 0.6 | 0.7 | 1.1 | 0.5 | 0.3 | >1.5 |
| Abs EO (G/L) | 0.1 | 0.0 | 0.1 | 0.2 | 0.1 | 0.2 | 0.2 | 0.1 | 0.2 | 0.2 | 0.1 | >1.5 |
| Abs BA (G/L) | 0.1 | 0.0 | 0.1 | 0.2 | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.1 | >0.3 |
| % NRBC | 0.1 | 0.0 | 0.0 | 0.3 | 0.1 | 0.2 | 0.1 | 0.1 | 0.5 | 0.1 | 0.1 | >2.0 |
| Abs NRBC (G/L) | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.00 | 0.05 | 0.01 | 0.00 | |
| MDS-LS | −6.5 | −8.7 | −54.4 | −10.4 | −16.5 | −41.9 | −23.1 | −16.3 | −4.0 | −2.6 | −21.5 | <0.0 |
Abbreviations: F, female; M, male; NA, not applicable; IPSS-R, revised international prognostic scoring system; RCC, red cell concentrates; N, no; Y, yes; RBC, red blood cells; Hb, haemoglobin; Hct, haematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular haemoglobin; MCHC, mean corpuscular haemoglobin concentration; RDW, red cell distribution width; Plt, platelets; MPV, mean platelet volume; WBC, white blood cells; NE, neutrophils; LY, lymphocytes; MO, monocytes; EO, eosinophils; BA, basophils; NRBC, nucleated red blood cells; Abs, absolute value; MDS-LS, MDS-likelihood score.