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Chemical structures of the hcGAS-binding inhibitors used in this study with their protein data bank (PDB) names. Tricyclic pyridoindole core for JUM (pyrazole ring) and JUJ (2-amino pyridine ring), diazolo-pyrimidine aromatic core for KHM, KKP, and KKM, tetrazolo-pyrimidine aromatic core for 8ZM and 9BV (thiazole ring), bi (1, 2, 4-triazole) core for ER9, tricyclic benzimidazole core for 9BY, and pyridine and pyrimidine rings for 9BS are shown.
