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. 2021 Jan 25;22(3):1171. doi: 10.3390/ijms22031171

Table 5.

Roles of CirRNAs associated with PKM2 in cancer.

CircRNA Research Model Targeted Pathways Mediator Effects on PKM2 Expression Biological/Physiological Effects Significance
Circ-MAT2B Hepatocellular Carcinoma (HCC) Glycolysis
Cell proliferation
Invasion
miR-338-3p Overexpression of Circ-MAT2B increased protein and mRNA PKM2 levels Circ-MAT2B overexpression increases HCC glucose utilization, tumor growth, and metastasis in vivo
Circ-MAT2B overexpression promoted glycolysis, cell proliferation, migration, and invasion in vitro under hypoxia [282]
Circ-MAT2B is associated with and predicts poor prognosis of HCC Targeting circ-MAT2B may alleviate HCC burden
Circ-FOXM1 Melanoma Proliferation
Glycolysis
Invasion
Apoptosis
miR-143-3p Silencing CircFOXM1
decreased PKM2 protein levels
Increased proliferation, glycolysis, motility, and decreased apoptosis [374] Circ-FOXM1 may promote melanoma progression through the miR-143-3p/FLOT2 axis
Circ-NRIP1 Gastric Cancer Proliferation
Migration
Glycolysis
Apoptosis
miR-186-5p Silencing of circ-NRIP1 decreased PKM2 protein levels Circ-NRIP1 KD decreased proliferation, migration, and glycolysis but induced apoptosis [375] Circ-NRIP1 promoted carcinogenesis and may have potential in prognostic and clinical application
Circ-FOXP1 Gallbladder
Cancer
Proliferation
Migration
Invasion
Apoptosis
Glycolysis
miR-370 Silencing of circFOXP1 resulted in a partial reduction in PKM2 protein level Promotes proliferation, invasion, migration and decreases apoptosis [376] Circ-FOXP1 may sponge miR-370 and promote PKLR expression, enhancing tumor progression
Circ-RNA hsa_circ_0005963 (ciRS-122) CRC Glycolysis
Apoptosis
miR-122 Exosome delivery of
CiRS-122 upregulated PKM2 levels
CiRS-122 delivery may promote drug resistance and glycolysis, and exosome-delivered siRNA appeared to reverse the resistance to treatment [377] CiRS-122 silencing may promote enhanced therapeutic effectiveness against oxaliplatin-resistant CRC