Figure 4.

Treatment with elacridar (10 mg/kg) i.p. for 28 days altered the expression Aβ transport proteins in isolated microvessels from TgSwDI mouse brains. Representative Western blot and densitometry analysis of P-gp, BCRP, LRP1, and RAGE, presented as fold change by elacridar on each protein compared to vehicle treatment, demonstrated that elacridar reduced the expression of P-gp and BCRP, while increased RAGE. Statistical analysis was determined by Student’s t-test. Data represented as mean ± SEM of n = 5 mice per group, ns = not significant; * p < 0.05 compared to vehicle-treated mice. kDa indicates the molecular weight of analyzed proteins.