Table 1.

Summary of the companies that provide in vitro models and their technical production methods with strengths and weaknesses.

Company	Product Name	Country	Strength	Weakness	Scientific Ref
Mimetas	OrganoPlateTM	Netherlands	Multiple assays in one plate, able to apply various cell types (neurons, hepatocytes, endothelial cell, etc.)	High cell density (108 cells/cm3), organ specific biochemical environment, cannot provide a one directional flow	[23]
Emulate	Liver-Chip	USA	Cyclic stretch and pneumatic controller to mimic the environment of the tissue	No 3D environment	[24]
CN Bio	PhysioMimix TM	UK	Membrane based 3D environment, transwell plate but has a fluid circulation	Less number of assays in one plate	[25]
TissUse	HUMIMIC CHIP	Germany	Multi-organ platform	Less number of assays in one plate	[26]
Organovo	ExVive3D TM, NovoGen Bioprinter®	USA	3D bioprinting technology (mimic the physical environment of the tissue well)	No microfluidic condition	[27]